- The Department was established at the College when the Arts subject courses of undergraduate wing of University College shifted to Kariavattom during the year 1993 -1994
- During 1996, all the undergraduate courses were shifted back to University College and the courses of Biotechnology, Biochemistry, Computer Science and Statistics were introduced at the undergraduate level and the college was renamed as Government College, Kariavattom in 1997.
- Subsequently in 1998 Geography course and in 1999, , two restructured double main Physics & Computer Application and Chemistry & Industrial Chemistry were introduced at the undergraduate level
- The Department offers the Vocational Core Subject in B.Sc Biotechnology Three main Course.
- Offers the complementary subject to the B.Sc. Biochemistry course
- It follows the syllabus and course pattern prescribed by the University of Kerala.